Delta variant of coronavirus could evade immune system, finds study
Darpan News Desk IANS, 12 Sep, 2022 12:29 PM
Hyderabad, Sep 12 (IANS) The human immune system can't produce the defence molecules against the Delta variant as effectively as against the other variants of coronavirus, revealed a study.
Dr. Krishnan Harshan's group led the study, in collaboration with Dr. Divya Tej Sowpati's group at CSIR-Centre for Cellular and Molecular Biology, to try to understand if hosts, that is humans infected by the virus, react differently to the different SARS-CoV-2 variants.
In this study published in Microbiology Spectrum journal, the researchers found that the immune system could not produce the defence molecules against the Delta variant as effectively as the other variants. While infection due to the other four variants alerted the immune system quickly, the Delta variant could silently replicate in the host cells.
In the last almost three years, there have been many SARS-CoV-2 variants spreading across the world. Their outcomes have varied greatly, with the Delta variant being the deadliest.
The researchers selected five different SARS-CoV-2 variants and studied how the human immune system responds to the variants. The studied variants included Alpha, Delta, and three other variants that emerged before the Alpha variant. Upon viral infection, the first line of attack by the host's immune system is by producing certain defence chemicals that break down the viruses. The researchers studied how their production responds to these five variants.
"We infected the human cells in a cell culture system with these different variants of the virus and monitored the production of known immune defence molecules and the activation of signaling pathways associated with them," said Dixit Tandel, the first author of the study.
"We navigated through the hundreds of immune pathways known to us using high throughput sequencing and analysis," said Dr. Nitesh Kumar Singh, who worked on the project with Dr Sowpati.
"We have identified that molecular mechanisms regulating the host immune response have not been as potent against the Delta variant of SARS-CoV-2. This also includes the production of interferons, immune molecules often used for antiviral therapies. The study hints at why the Delta variant could spread more easily," said Dr. Krishnan Harshan, the lead investigator in this work.
He added that the study also helps us understand how viruses evolve with changing effects on human hosts.
SHE teams, a division of Telangana Police for enhanced safety and security of women, caught these men red-handed while misbehaving with women by touching them inappropriately, stalking them and taking their pictures near Ganesh pandals across the city.
The court awarded jail term to Jitendra Kumar Jatav (candidate) and Gulab Singh Patel (solver) besides slapping a fine of Rs 13,100 on each of them. The CBI had registered the case on August 4, 2015 in compliance of the order of the Supreme Court. The FIR was registered against the accused and others at Dehat police station in Bhind on charges of impersonation.
The threat came four days after the DAV Public School got a similar threat, which later proved to be a prank made by three students of the school. A message uploaded on social media on Monday evening read that there would be a blast in Spring Dale School on September 16 .
The official said that the group of 23 Sudanese gathered and attempted to clear the green channel by creating ruckus and divert attention of the customs officers. "The Sudanese passengers deliberately created a ruckus at customs arrival area through visible signs and acts of aggression including shouting at the officers and even indulging in physical bouts," the official said.
The NIA had been mulling action against big gangsters like Bishnoi, Kapil Sangwan and Neeraj Bawana and their aides. The Union Home Ministry had asked the NIA to uproot their entire network as they were involved in targeted killings and were acting like terrorists.
The Chief Minister said investigation into the case was almost completed.. Phogat had come to Goa on August 22 and was staying at a hotel in Anjuna. She felt uneasy that night and the next morning, she was taken to the St. Anthony's hospital where she was declared brought dead.
