Delta variant of coronavirus could evade immune system, finds study
Darpan News Desk IANS, 12 Sep, 2022 12:29 PM
Hyderabad, Sep 12 (IANS) The human immune system can't produce the defence molecules against the Delta variant as effectively as against the other variants of coronavirus, revealed a study.
Dr. Krishnan Harshan's group led the study, in collaboration with Dr. Divya Tej Sowpati's group at CSIR-Centre for Cellular and Molecular Biology, to try to understand if hosts, that is humans infected by the virus, react differently to the different SARS-CoV-2 variants.
In this study published in Microbiology Spectrum journal, the researchers found that the immune system could not produce the defence molecules against the Delta variant as effectively as the other variants. While infection due to the other four variants alerted the immune system quickly, the Delta variant could silently replicate in the host cells.
In the last almost three years, there have been many SARS-CoV-2 variants spreading across the world. Their outcomes have varied greatly, with the Delta variant being the deadliest.
The researchers selected five different SARS-CoV-2 variants and studied how the human immune system responds to the variants. The studied variants included Alpha, Delta, and three other variants that emerged before the Alpha variant. Upon viral infection, the first line of attack by the host's immune system is by producing certain defence chemicals that break down the viruses. The researchers studied how their production responds to these five variants.
"We infected the human cells in a cell culture system with these different variants of the virus and monitored the production of known immune defence molecules and the activation of signaling pathways associated with them," said Dixit Tandel, the first author of the study.
"We navigated through the hundreds of immune pathways known to us using high throughput sequencing and analysis," said Dr. Nitesh Kumar Singh, who worked on the project with Dr Sowpati.
"We have identified that molecular mechanisms regulating the host immune response have not been as potent against the Delta variant of SARS-CoV-2. This also includes the production of interferons, immune molecules often used for antiviral therapies. The study hints at why the Delta variant could spread more easily," said Dr. Krishnan Harshan, the lead investigator in this work.
He added that the study also helps us understand how viruses evolve with changing effects on human hosts.
The accused has been identified as Noori Ibrahim, a resident of Vellore, Tamil Nadu. Her agent, Ibraheem Keethadth, a resident of Bengaluru, has also been arrested.
Sisodia concluded with "dissatisfaction" over unchanged Income Tax slab. "Today, this country needed some relief in the income tax slabs. This would have helped our middle class regain purchasing power and enter the markets. This would have naturally helped the economy grow."
Observing the 3rd World Neglected Tropical Diseases (NTD) Day as a key moment to highlight the global community's commitment to ending these, India joined close to 40 other nations to illuminate iconic landmarks to raise awareness. This year, India lit up the New Delhi Railway Station in purple and orange hues to mark the occasion.
The accused have been identified as Nitin Pratap alias Atul and Sandeep Kumar -- residents of Firozabad in Uttar Pradesh. Police said the accused used a Suzuki Gixxer motorcycle for the last two months to commit the crime in Gurugram and Rajasthan, and they used to travel from Tapukara in Rajasthan once a week to snatch mobile phones.
The deceased, identified as Megha Kayal, 40, was working as a doctor in London Milton Keynes University Hospital. Prior to this, she was a doctor at Apollo hospital, Sarita Vihar, Delhi.
A gofundme has raised US$70,000 for the victim family. The bodies of the four family members – who have been identified after autopsies as Jagdish Patel, 39, his wife Vaishaliben Patel, 37, daughter Vihangi Patel, 11, and son Dharmik Patel, 3 – are currently lying in a morgue in Winnipeg.
