Delta variant of coronavirus could evade immune system, finds study
Darpan News Desk IANS, 12 Sep, 2022 12:29 PM
Hyderabad, Sep 12 (IANS) The human immune system can't produce the defence molecules against the Delta variant as effectively as against the other variants of coronavirus, revealed a study.
Dr. Krishnan Harshan's group led the study, in collaboration with Dr. Divya Tej Sowpati's group at CSIR-Centre for Cellular and Molecular Biology, to try to understand if hosts, that is humans infected by the virus, react differently to the different SARS-CoV-2 variants.
In this study published in Microbiology Spectrum journal, the researchers found that the immune system could not produce the defence molecules against the Delta variant as effectively as the other variants. While infection due to the other four variants alerted the immune system quickly, the Delta variant could silently replicate in the host cells.
In the last almost three years, there have been many SARS-CoV-2 variants spreading across the world. Their outcomes have varied greatly, with the Delta variant being the deadliest.
The researchers selected five different SARS-CoV-2 variants and studied how the human immune system responds to the variants. The studied variants included Alpha, Delta, and three other variants that emerged before the Alpha variant. Upon viral infection, the first line of attack by the host's immune system is by producing certain defence chemicals that break down the viruses. The researchers studied how their production responds to these five variants.
"We infected the human cells in a cell culture system with these different variants of the virus and monitored the production of known immune defence molecules and the activation of signaling pathways associated with them," said Dixit Tandel, the first author of the study.
"We navigated through the hundreds of immune pathways known to us using high throughput sequencing and analysis," said Dr. Nitesh Kumar Singh, who worked on the project with Dr Sowpati.
"We have identified that molecular mechanisms regulating the host immune response have not been as potent against the Delta variant of SARS-CoV-2. This also includes the production of interferons, immune molecules often used for antiviral therapies. The study hints at why the Delta variant could spread more easily," said Dr. Krishnan Harshan, the lead investigator in this work.
He added that the study also helps us understand how viruses evolve with changing effects on human hosts.
Hitting out at Navjot Singh Sidhu, the BJP on Monday said that Punjab Congress chief is creating unwarranted fears in the minds of farmers by suggesting that the Centre had plans to do away with the MSP system.
After literally turning a deaf ear to the farmers’ issues for over a year, Indian Prime Minister Narendra Modi on Friday, November 19, 2021, in a dramatic move, announced the withdrawal of the three controversial farm laws, which were at the heart of the farmers’ protests across the country.
Earlier, Dhesi sent a letter, signed by over 100 British MPs and Lords, to Prime Minister Boris Johnson on the ongoing farmers' protests, asking him to raise this matter with his Indian counterpart Narendra Modi when they next liaise.
The Chief Minister told the media here that for more than a year since the Central government had brought three agriculture laws for the benefit of farmers, especially small and marginal ones, unfortunately, some farmer unions had been protesting on the Delhi borders.
While the Centre's announcement to repeal three farm laws is seen as a political decision with eye on forthcoming assembly polls in five states, the BJP claims that it has nothing to do with elections as the party has won many states after laws were passed by the Parliament.
On January 12 this year, the Supreme Court had stayed the implementation of the three farm laws after scores of farmers from Punjab, Haryana and Uttar Pradesh pitched their tents on various Delhi borders in protest against the three laws.
