Delta variant of coronavirus could evade immune system, finds study
Darpan News Desk IANS, 12 Sep, 2022 12:29 PM
Hyderabad, Sep 12 (IANS) The human immune system can't produce the defence molecules against the Delta variant as effectively as against the other variants of coronavirus, revealed a study.
Dr. Krishnan Harshan's group led the study, in collaboration with Dr. Divya Tej Sowpati's group at CSIR-Centre for Cellular and Molecular Biology, to try to understand if hosts, that is humans infected by the virus, react differently to the different SARS-CoV-2 variants.
In this study published in Microbiology Spectrum journal, the researchers found that the immune system could not produce the defence molecules against the Delta variant as effectively as the other variants. While infection due to the other four variants alerted the immune system quickly, the Delta variant could silently replicate in the host cells.
In the last almost three years, there have been many SARS-CoV-2 variants spreading across the world. Their outcomes have varied greatly, with the Delta variant being the deadliest.
The researchers selected five different SARS-CoV-2 variants and studied how the human immune system responds to the variants. The studied variants included Alpha, Delta, and three other variants that emerged before the Alpha variant. Upon viral infection, the first line of attack by the host's immune system is by producing certain defence chemicals that break down the viruses. The researchers studied how their production responds to these five variants.
"We infected the human cells in a cell culture system with these different variants of the virus and monitored the production of known immune defence molecules and the activation of signaling pathways associated with them," said Dixit Tandel, the first author of the study.
"We navigated through the hundreds of immune pathways known to us using high throughput sequencing and analysis," said Dr. Nitesh Kumar Singh, who worked on the project with Dr Sowpati.
"We have identified that molecular mechanisms regulating the host immune response have not been as potent against the Delta variant of SARS-CoV-2. This also includes the production of interferons, immune molecules often used for antiviral therapies. The study hints at why the Delta variant could spread more easily," said Dr. Krishnan Harshan, the lead investigator in this work.
He added that the study also helps us understand how viruses evolve with changing effects on human hosts.
9 persons, including four farmers, were killed in the violence that had erupted during a farmers' protest in Lakhimpur Kheri. A bench headed by Chief Justice N.V. Ramana and comprising justices Surya Kant and Hima Kohli will hear the matter on Thursday. The matter has been listed as 'violence in Lakhimpur Kheri (UP) leading to loss of life'.
Canadian MP Tim S. Uppal said he was shocked to learn about the brazen attack on protesting farmers. Another Canadian MP Ruby Sahota said she was heartbroken to learn about the violence directed at protesting farmers.
The demand made by citizens primarily mirrored their right to clean air and the right to breathe, underlining the reality that Punjab is home to some of India's most polluted towns, including Mandi Gobindgarh, Amritsar, Jalandhar, Ludhiana, Khanna, and Patiala.
The case was assigned to the division bench of Justices A.G. Masih and Ashok Kumar Verma. Earlier, the case was being heard by the bench of Justices Rajan Gupta and Ajay Tewari but the latter recused himself from hearing the case on September 1.
Furnishing details about the incident, Additional DCP-2 Nishant Gupta told IANS that they had received information about a firing incident in the northeast Delhi area on October 1.
The activists of Punjab Congress will walk towards Lakhimpur Kheri in Uttar Pradesh if Priyanka Gandhi is not released and the Union Minister's son accused of murder not arrested, said state party President Navjot Sidhu on Tuesday.
