Delta variant of coronavirus could evade immune system, finds study
Darpan News Desk IANS, 12 Sep, 2022 12:29 PM
Hyderabad, Sep 12 (IANS) The human immune system can't produce the defence molecules against the Delta variant as effectively as against the other variants of coronavirus, revealed a study.
Dr. Krishnan Harshan's group led the study, in collaboration with Dr. Divya Tej Sowpati's group at CSIR-Centre for Cellular and Molecular Biology, to try to understand if hosts, that is humans infected by the virus, react differently to the different SARS-CoV-2 variants.
In this study published in Microbiology Spectrum journal, the researchers found that the immune system could not produce the defence molecules against the Delta variant as effectively as the other variants. While infection due to the other four variants alerted the immune system quickly, the Delta variant could silently replicate in the host cells.
In the last almost three years, there have been many SARS-CoV-2 variants spreading across the world. Their outcomes have varied greatly, with the Delta variant being the deadliest.
The researchers selected five different SARS-CoV-2 variants and studied how the human immune system responds to the variants. The studied variants included Alpha, Delta, and three other variants that emerged before the Alpha variant. Upon viral infection, the first line of attack by the host's immune system is by producing certain defence chemicals that break down the viruses. The researchers studied how their production responds to these five variants.
"We infected the human cells in a cell culture system with these different variants of the virus and monitored the production of known immune defence molecules and the activation of signaling pathways associated with them," said Dixit Tandel, the first author of the study.
"We navigated through the hundreds of immune pathways known to us using high throughput sequencing and analysis," said Dr. Nitesh Kumar Singh, who worked on the project with Dr Sowpati.
"We have identified that molecular mechanisms regulating the host immune response have not been as potent against the Delta variant of SARS-CoV-2. This also includes the production of interferons, immune molecules often used for antiviral therapies. The study hints at why the Delta variant could spread more easily," said Dr. Krishnan Harshan, the lead investigator in this work.
He added that the study also helps us understand how viruses evolve with changing effects on human hosts.
Amarinder Singh said MP Pratap Bajwa had already demanded a district status for Batala, in his letter dated August 11 and had cited Batala's historic importance and its connection with Guru Nanak Dev, who had married Mata Sulakhni in Batala in 1487.
A source in the security set up said that Srinagar alone recorded 16 terror-related incidents, 21 per cent of the total of 75 incidents reported from across the Valley till so far this year, leaving behind the traditional hotbed of terrorism of Pulwama, Anantnag and Shopian.
Congress chief spokesperson, Randeep Surjewala said in a statement, "The Khattar government has lost the confidence and the mandate of the people and it should leave. When your party can talk to the Taliban, why not farmers."
Researchers from National Centre for Disease Control, Delhi, under the Ministry of Health; CSIR Institute of Genomics and Integrative Biology, Delhi, and University of Cambridge in the UK examined how the Delta variant was able to evade the immune response.
Senior Superintendent of Police Swapan Sharma told the media that Babbi was in touch with the members of the Ajaib Khan gang lodged in a Sangrur jail with whom he had hatched a conspiracy to eliminate rival gangsters Mani Sheron and Feteh Nagri.
Prabhjot Singh Katri was found murdered early on Sunday morning near his residence in the city of Truro in Nova Scotia. The victim came to Canada from India in 2017 for higher studies. After finishing his studies, he was on a work visa and was driving a cab to earn his livelihood.
