Delta variant of coronavirus could evade immune system, finds study
Darpan News Desk IANS, 12 Sep, 2022 12:29 PM
Hyderabad, Sep 12 (IANS) The human immune system can't produce the defence molecules against the Delta variant as effectively as against the other variants of coronavirus, revealed a study.
Dr. Krishnan Harshan's group led the study, in collaboration with Dr. Divya Tej Sowpati's group at CSIR-Centre for Cellular and Molecular Biology, to try to understand if hosts, that is humans infected by the virus, react differently to the different SARS-CoV-2 variants.
In this study published in Microbiology Spectrum journal, the researchers found that the immune system could not produce the defence molecules against the Delta variant as effectively as the other variants. While infection due to the other four variants alerted the immune system quickly, the Delta variant could silently replicate in the host cells.
In the last almost three years, there have been many SARS-CoV-2 variants spreading across the world. Their outcomes have varied greatly, with the Delta variant being the deadliest.
The researchers selected five different SARS-CoV-2 variants and studied how the human immune system responds to the variants. The studied variants included Alpha, Delta, and three other variants that emerged before the Alpha variant. Upon viral infection, the first line of attack by the host's immune system is by producing certain defence chemicals that break down the viruses. The researchers studied how their production responds to these five variants.
"We infected the human cells in a cell culture system with these different variants of the virus and monitored the production of known immune defence molecules and the activation of signaling pathways associated with them," said Dixit Tandel, the first author of the study.
"We navigated through the hundreds of immune pathways known to us using high throughput sequencing and analysis," said Dr. Nitesh Kumar Singh, who worked on the project with Dr Sowpati.
"We have identified that molecular mechanisms regulating the host immune response have not been as potent against the Delta variant of SARS-CoV-2. This also includes the production of interferons, immune molecules often used for antiviral therapies. The study hints at why the Delta variant could spread more easily," said Dr. Krishnan Harshan, the lead investigator in this work.
He added that the study also helps us understand how viruses evolve with changing effects on human hosts.
Murder of Punjabi singer Shubhdeep Singh, popularly known as Sidhu Moosewala, allegedly on behalf of the Lawrence Bishnoi gang, took place on May 29, 2022. Goldy Brar is a prime accused in the case. He has been accused of hiring gangsters to eliminate Moosewala.
The official informed that they received a call about the fire incident around 5.00 a.m. at the Main Tikona Park, Jamia Nagar in South-East Delhi after which as many as 11 fire tenders were immediately pressed into service. The cause of the fire is yet to be ascertained.
The BSF is interrogating the arrested smugglers. This is the second major incident of drugs being caught on the border in the last one week. Earlier also drug was dropped into India by using drones.
Donning T-shirts with pictures of Moosewala printed on them with the message 'Legends never die', some of the fans gathered to attend the 'bhog' ceremony of the singer.
A spokesperson for the police said on May 19, 10 days before the killing of Moosewala, it had already sent the proposal to the Central Bureau of Investigation (CBI) to issue Red Corner notice against Brar, which will pave the way for his extradition to India.
The accused was identified as Sidhesh Hiraman Kamle, alias Mahakaal. "He was arrested in a joint operation conducted by a team of Special Cell and Maharashtra Police," Special Commissioner of Police, Special Cell, H.S. Dhaliwal, said.
