Tuesday, January 31, 2023
ADVT 
Health

Gene that naturally protects people against Covid discovered

Darpan News Desk IANS, 22 Nov, 2022 01:06 PM
  • Gene that naturally protects people against Covid discovered

Sao Paulo, Nov 22 (IANS) A team of Brazilian researchers has discovered that a gene can protect people, even those aged 90 and above, from the deadly Covid disease.

Two research papers found that the frequency of variants of the gene 'MUC22' was twice as high in the mild Covid-19 group as in severe patients, and higher still in resilient super-agers.

This gene belongs to the "mucin" family and is associated with the production of mucus, which lubricates and protects the airways.

On the other hand, overproduction of mucus has been linked to the lung inflammation typical of severe Covid-19.

One research paper involved a group of resilient older people aged 90 or more, and the other analyzed a case of severe Covid-19 in identical twins, only one of whom suffered from long-term symptoms of the disease.

"If we can really prove that some genes promote resistance to SARS-CoV-2, the same may also be true for other viruses. More research can then be based on these findings to try to understand the mechanisms underlying this resilience and develop medications that enhance protection against viral infections," said Mayana Zatz, professor of Human and Medical Genetics at the University of Sao Paulo and lead author of the articles published in the journal Frontiers in Immunology, told Agencia FAPESP.

In one study, the researchers analyzed data sets for a cohort of 87 "resilient super-agers" a" patients over 90 who recovered from mild Covid-19 or remained asymptomatic after testing positive for SARS-CoV-2. Their average age was 94.

One woman was 114 at the time of the study and was considered the oldest patient to have recovered from the disease in Brazil.

They found that mutations in MUC22 are technically termed "missense" variants -- DNA changes that result in different amino acids being encoded at particular positions in the resulting proteins.

According to the article, they may weaken the hyperactive immune responses to Covid virus and play an important role in protecting the airways against the virus. One of the hypotheses entertained by the authors is, therefore, that the resilient subjects may have optimal control of mucin production.

"It may be the case that the missense variants interfere with not only mucus production but also its composition since amino acids are switched. We need to conduct more studies to understand how they act during infections and in healthy people," said Erick Castelli, a researcher at Sao Paulo State University's Medical School (FM-UNESP).

MORE Health ARTICLES

Indian drug 2DG can reduce heart damage by coronavirus, find US researchers

Indian drug 2DG can reduce heart damage by coronavirus, find US researchers

The researchers said that fortunately, 2DG is inexpensive and is used regularly in laboratory research and is being used in clinical trials in India. The drug has not yet been approved by the US Food and Drug Administration (FDA) to treat the disease.

Indian drug 2DG can reduce heart damage by coronavirus, find US researchers

B.C. aims to expand access to menstrual products

B.C. aims to expand access to menstrual products

Nicholas Simons, the minister of social development and poverty reduction, says half of the people who menstruate in B.C. have struggled to buy the products they need at some point in their lives.

B.C. aims to expand access to menstrual products

From Local to Global: Sikh Health Foundation

From Local to Global:  Sikh Health Foundation

In process is also a documentary-style feature that will shine light on South Asian youth’s actions to help mobilize change in South Asian communities during the pandemic. The hope is that this documentary will be useful for future health crises, through which governments and organizations can see, firsthand, how to help create change.

From Local to Global: Sikh Health Foundation

Most Effective Herbs to prevent Cancer

Most Effective Herbs to prevent Cancer

Through nutrition, humans have evolved a sophisticated and cooperative system of antioxidant defence mechanisms against toxic oxygen intermediates, according to biochemical and epidemiological evidence. This suggests that increasing antioxidant intake through nutrition may significantly reduce the risk of cancer.

Most Effective Herbs to prevent Cancer

Kitchen tip: retain natural goodness of cold pressed virgin coconut oil

Kitchen tip: retain natural goodness of cold pressed virgin coconut oil

Consuming cold-pressed virgin Coconut oil which is pure, unrefined, and extracted from freshly harvested coconuts is an ideal choice for cooking, healthier than other refined vegetable oils. The cold pressing technology helps preserve and retain the natural goodness, vital nutrients, rich aroma and flavour of fresh coconuts.

Kitchen tip: retain natural goodness of cold pressed virgin coconut oil

Report finds many Canadians lag on fitness

Report finds many Canadians lag on fitness

It gives grown-ups an "F" for sedentary behaviour after finding 88 per cent of surveyed adults said they were relatively inactive more than eight waking hours per day. Examples of such behaviour include sitting while watching television, playing video games, listening to music, doing paperwork or commuting.

 

 

Report finds many Canadians lag on fitness

PrevNext